QuickView for complement c3;jsessionid=C84077673EEE2DFC49BE9C8A1B87DFD0;jsessionid=E1BAA7152EF5DDE63196C836FE74197C (gene)

Gene Symbol:

C3 Mus musculus

Full name:

complement component 3

Synonyms:

AI255234, ASP, HSE-MSF, Plp, complement C3, acylation stimulating protein, complement component 3d, complement factor 3

Genomic Location:

Chr 17: 57343396-57367559

Description:

This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infecti...

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This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBPB_01

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